Catalog Number:

315-05

Synonyms:

Immune Interferon, type II interferon, T cell interferon, MAF

IFN-γ是由CD4和CD8 T淋巴細(xì)胞，以及活化NK細(xì)胞產(chǎn)生的酸不穩(wěn)定干擾素。的IFN-γ受體存在于大多數(shù)免疫細(xì)胞，其響應(yīng)通過(guò)增加I類MHC蛋白的表面表達(dá)，以IFN-γ信號(hào)傳導(dǎo)。這促進(jìn)了抗原與T-輔助（CD4+）細(xì)胞的呈現(xiàn)。的IFN-γ的抗原呈遞細(xì)胞和抗原識(shí)別B和T淋巴細(xì)胞的信令，調(diào)節(jié)免疫應(yīng)答的抗原特異性相。此外，IFN-γ刺激了許多淋巴樣細(xì)胞的功能，包括巨噬細(xì)胞，NK細(xì)胞和嗜中性粒細(xì)胞的抗微生物和抗腫瘤應(yīng)答。人IFN-γ是物種特異性的，具有生物活性僅在人類和靈長(zhǎng)類動(dòng)物細(xì)胞。重組鼠IFN-γ是含有134個(gè)氨基酸殘基15.6 kDa的蛋白質(zhì)。

Description:

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes, as well as activated NK cells.  IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins.  This promotes the presentation of antigen to T-helper (CD4+) cells.  IFN-γ signaling in antigen-presenting, cells and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response.  Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils.  Human IFN-γ is species-specific and is biologically active only in human and primate cells.  Recombinant Murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.

AA Sequence:

MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQSQII SFYLRLFEVL KDNQAISNNI SVIESHLITT FFSNSKAKKD AFMSIAKFEV NNPQVQRQAF NELIRVVHQL LPESSLRKRK RSRC

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The expected ED₅₀ is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁶ units/mg.

Cross Reactivity:

Rabbit, Rat, Mouse, Mouse + Chicken, Human, Cow, N/A, Mouse + Parasite